Key terms for
PBD-ZSD


Adjunctive therapy

A treatment that is not intended to be used alone. Instead, it is intended to be used in combination with a primary treatment.

Alanine transaminase test (ALT)

The alanine transaminase/aminotransferase test, also known as ALT, is one of a group of tests known as liver function tests (or LFTs) and is used to monitor damage to the liver.

Aspartate transaminase test (AST)

The aspartate transaminase/aminotransferase test measures levels of AST, an enzyme released into the blood when certain organs or tissues, particularly the liver and heart, are injured.

Bile

Bile is a fluid that contains water, certain minerals, and other materials including bile acids, lipids, cholesterol, and an orange-yellow pigment (bilirubin). Bile aids in digestion and absorption of dietary fats, vitamins, and other nutrients and it aids in the elimination of excess cholesterol, bilirubin, waste, and toxins from the body.

Bile acids

Bile acids are compounds that aid in digestion and absorption of dietary fats, vitamins, and other nutrients and in the elimination of excess cholesterol, bilirubin, waste, and toxins from the body.

Cholestasis

When bile flow is reduced or stopped.

Cholic acid

One of the primary bile acids made in the liver under healthy conditions.

Enzyme

A compound in the body that enables certain chemical processes to occur.

Gamma glutamyltransferase test (GGT)

A blood test that measures GGT and is used to detect damage to the liver or bile ducts. Elevated levels may indicate cholestasis and/or biliary obstruction.

Infantile Refsum disease (IRD)

A disorder affecting peroxisomal biogenesis belonging to the PBD-ZSD family. IRD is the least severe form of the disorder. Patients generally survive longer, and sometimes live into their adult life.

Jaundice

Jaundice is a condition in which a person’s skin and the whites of the eyes are discolored yellow due to an increased level of bile pigments in the blood resulting from liver disease.

Liver function tests (LFTs)

A group of blood tests that detect inflammation and damage to the liver. They can also check how well the liver is working.

Neonatal adrenoleukodystrophy

A disorder affecting peroxisomal biogenesis belonging to the PBD-ZSD family. Patients affected with this disorder may live to school age.

Peroxisomal biogenesis disorder-Zellweger spectrum disorder (PBD-ZSD)

A rare, genetic condition caused by the loss of peroxisome function. Previously, PBD-ZSD was thought to be 3 separate diseases known by various names, so you may hear other names used for this disorder. It is now believed that PBD-ZSD is 1 disease with a range of symptoms and severity.

Peroxisomes

Peroxisomes can be found in nearly every cell in the body. They help make bile acids, which digest fats and fat-soluble vitamins that are important nutrients for growth and development.

PEX genes

Genes that encode for proteins known as peroxins, or peroxisomal biogenesis factors, which are found in the peroxisomes. Defects in PEX genes are associated with several peroxisomal disorders.

Steatorrhea

The excretion of abnormal quantities of fat with feces, owing to reduced absorption of fat by the intestine.

Zellweger syndrome

A disorder affecting peroxisomal biogenesis belonging to the PBD-ZSD family. Zellweger syndrome is the most severe form of PBD-ZSD and is often fatal within the first 12 years of a child’s life.

WHAT IS CHOLBAM® (cholic acid) capsules?

CHOLBAM is a prescription medicine. It is a bile acid used for

  • Treatment of bile acid synthesis disorders (malfunction in the production of bile acid in the liver) due to a lack of a single enzyme responsible for bile acid production.
  • Treatment (in addition to other treatments) of peroxisomal disorders (a loss of function in important parts of the cell), including Zellweger spectrum disorders, in patients who show signs or symptoms of liver disease, pale stools due to too much fat, or problems resulting from not absorbing certain vitamins (A, D, E, K).

The safety and effectiveness of CHOLBAM on symptoms outside of the liver have not been studied.

IMPORTANT SAFETY INFORMATION

CHOLBAM may not be right for you. Before taking CHOLBAM, tell your doctor about:

  • All health conditions you may have and any medications you may be taking.
  • If you are pregnant or plan to become pregnant.
  • If you are breastfeeding or plan to breastfeed.

 

What are the possible side effects of CHOLBAM?

  • Serious Side Effects: You will need to undergo laboratory testing periodically while on treatment to assess liver function. CHOLBAM may worsen liver function. Tell your doctor right away if you experience symptoms associated with worsening of liver function (e.g., skin or the whites of eyes turn yellow, urine turns dark or brown [tea colored], pain on the right side of stomach, bleeding or bruising occurs more easily than normal, or increased lethargy). Your doctor will decide if you need to discontinue treatment with CHOLBAM.
  • Most Common Side Effects: Diarrhea, acid reflux that damages the lining of the esophagus, discomfort and fatigue, yellowing of skin or eyes, skin lesion, nausea, abdominal pain, formation of growths in the intestinal tract, urinary tract infection, nerve damage causing change in sensation in extremities.

These are not all the possible side effects of CHOLBAM. Tell your doctor if you have any side effect that bothers you or that does not go away.

You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Mirum Pharmaceuticals at 1-855-MRM-4YOU.

Please see accompanying full Prescribing Information for additional Important Safety Information.

SEE MORE

WHAT IS CHOLBAM® (cholic acid) capsules?

CHOLBAM is a prescription medicine. It is a bile acid used for

  • Treatment of bile acid synthesis disorders (malfunction in the production of bile acid in the liver) due to a lack of a single enzyme responsible for bile acid production.
  • Treatment (in addition to other treatments) of peroxisomal disorders (a loss of function in important parts of the cell), including Zellweger spectrum disorders, in patients who show signs or symptoms of liver disease, pale stools due to too much fat, or problems resulting from not absorbing certain vitamins (A, D, E, K).

 

The safety and effectiveness of CHOLBAM on symptoms outside of the liver have not been studied.

IMPORTANT SAFETY INFORMATION

CHOLBAM may not be right for you. Before taking CHOLBAM, tell your doctor about:

  • All health conditions you may have and any medications you may be taking.
  • If you are pregnant or plan to become pregnant.
  • If you are breastfeeding or plan to breastfeed.

 

What are the possible side effects of CHOLBAM?

  • Serious Side Effects: You will need to undergo laboratory testing periodically while on treatment to assess liver function. CHOLBAM may worsen liver function. Tell your doctor right away if you experience symptoms associated with worsening of liver function (e.g., skin or the whites of eyes turn yellow, urine turns dark or brown [tea colored], pain on the right side of stomach, bleeding or bruising occurs more easily than normal, or increased lethargy). Your doctor will decide if you need to discontinue treatment with CHOLBAM.
  • Most Common Side Effects: Diarrhea, acid reflux that damages the lining of the esophagus, discomfort and fatigue, yellowing of skin or eyes, skin lesion, nausea, abdominal pain, formation of growths in the intestinal tract, urinary tract infection, nerve damage causing change in sensation in extremities.

These are not all the possible side effects of CHOLBAM. Tell your doctor if you have any side effect that bothers you or that does not go away.

You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Mirum Pharmaceuticals at 1-855-MRM-4YOU.

Please see accompanying full Prescribing Information for additional Important Safety Information.