Daily dosing for PBD-ZSD care
How is CHOLBAM available?
- CHOLBAM is available in 50-mg and 250-mg capsules
What is the recommended dose of CHOLBAM?
- The recommended dosage of CHOLBAM is 10 to 15 mg per kg of body weight taken by mouth once daily, or in 2 divided doses
- The doctor may consider starting with twice daily dosing as you or your loved one gets used to higher doses of cholic acid
- Talk to your or your loved one's doctor about the right dosage and how many capsules should be taken each day
How is CHOLBAM taken?
- CHOLBAM is taken by mouth (orally)
- Take CHOLBAM with food
- Take CHOLBAM at least 1 hour before or 4 to 6 hours after taking a bile acid binding resin or an aluminum-based antacid
- Do not crush or chew the capsules. For patients who cannot swallow capsules, see additional steps below
How often is CHOLBAM taken?
- CHOLBAM is taken once daily, or in 2 divided doses
Can I adjust the dose as growth occurs?
- Do not adjust the dose without first consulting with your or your loved one's doctor
- The recommended dosage will change as weight changes. The doctor will adjust as needed, particularly during periods of rapid growth
While taking CHOLBAM, periodic lab testing to monitor liver function is recommended. Your or your loved one's doctor will monitor liver function every month for the first 3 months, then test less frequently throughout the year. If liver function does not improve within 3 months of starting treatment, or symptoms worsen, your or your loved one's doctor will discontinue CHOLBAM.
For patients who cannot swallow capsules
CHOLBAM capsules can be opened and the contents mixed with either infant formula or expressed breast milk (for younger children), or soft foods, such as mashed potatoes or apple puree (for older children and adults) in order to mask any unpleasant taste.
- Hold the capsule over the prepared liquid/food, gently twist open, and allow the contents to fall into the liquid/food.
- Mix the entire capsule contents with 1 or 2 tablespoons (15 mL-30 mL) of infant formula, expressed breast milk, or soft food, such as mashed potatoes or apple puree.
- Stir for 30 seconds.
- The capsule contents will remain as fine granules in the milk or food and will not dissolve.
- Administer the mixture immediately.
Tips for taking CHOLBAM: CHOLBAM capsules can also be opened and mixed with your or your loved one's favorite syrup (eg, chocolate syrup or maple syrup), stirred into a spoonful of yogurt or applesauce, or mixed with a coffee creamer.
How to receive CHOLBAM
Getting started on CHOLBAM is simple through Mirum Access Plus.
If you have any questions about Mirum Access Plus, contact us at: 1-855-MRM-4YOU (1-855-676-4968) Monday through Friday, 8:00 am to 8:00 pm ET, or download and sign the Mirum Access Plus Consent Form to sign up.
Talk to a health care provider to learn more about CHOLBAM.
There is a lot to learn about PBD-ZSD, and our video library may help
